Maud Menten

Life & Legacy

Maud Leonora Menten (March 20, 1879 – July 17, 1960) was a Canadian physician and chemist. As a bio-medical and medical researcher, she made significant contributions to enzyme kinetics and histochemistry, and invented a procedure that remains in use. She is primarily known for her work with Leonor Michaelis on enzyme kinetics in 1913. The paper has been translated from its written language of German into English.
Maud Menten was born in Port Lambton, Ontario and studied medicine at the University of Toronto (B.A. 1904, M.B. 1907, M.D. 1911). She was among the first women in Canada to earn a medical doctorate.
Since women were not allowed to participate in research in Canada at the time, Menten looked elsewhere to continue her work. In 1912, she moved to Berlin where she worked with Leonor Michaelis and co-authored their paper in Biochemische Zeitschrift, demonstrating that the rate of an enzyme-catalyzed reaction is proportional to the amount of the enzyme-substrate complex. This relationship between reaction rate and enzyme–substrate concentration is known as the Michaelis–Menten equation.
After working with Michaelis in Germany she entered graduate school at the University of Chicago where she obtained her Ph.D. in 1916. Her dissertation was entitled "The Alkalinity of the Blood in Malignancy and Other Pathological Conditions; Together with Observations on the Relation of the Alkalinity of the Blood to Barometric Pressure".
Menten joined the faculty of the University of Pittsburgh in 1923 and remained there until her retirement in 1950. She became an assistant professor and then an associate professor in the School of Medicine and was the head of pathology at the Children's Hospital of Pittsburgh. Her final promotion to full professor, in 1948, was at the age of 69 in the last year of her career. Her final academic post was as a research fellow at the British Columbia Medical Research Institute.